Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

Isolation and identification of compounds responsible for antioxidant capacity of euryale ferox seeds

Language

English

Abstract

Euryale ferox seed is consumed medicinally or for food in China. The present study revealed it to contain significant antioxidant activity, which may be associated with its medical applications as a proteinuria inhibitor of diabetic nephropathy. This study resulted in the identification of 3 new sesquineolignans, named euryalins A−C (13), and 16 known compounds, which were all first isolated from this plant apart from 5,7,4-trihydroxy-flavanone. The antioxidant potential of the partial isolates was evaluated using the DPPH radical scavenging assay and mesangial cellular assay. Compounds 2, rel-(2α,3β)-7-O-methylcedrusin (4), syringylglycerol-8-O-4-(sinapyl alcohol) ether (5), and (+)-syringaresinol (7) were found to be most active on DPPH assay, whereas compounds 2, 4, 7, (1R,2R,5R,6S)-2-(3,4-dimethoxyphenyl)-6-(3,4-dihydroxyphenyl)-3,7-dioxabicyclo[3.3.0]octane, and buddlenol E could significantly inhibit high glucose-stimulated reactive oxygen species production in mesangial cells. The results suggested that E. ferox seed could be considered as an excellent source of natural antioxidants and is useful in the prevention of diabetic nephropathy.

Keywords

antioxidant activity, Euryale ferox, lignans, Nymphaeaceae

Publication Date

2011

Source Publication Title

Journal of Agricultural and Food Chemistry

Volume

59

Issue

4

Start Page

1199

End Page

1204

Publisher

American Chemical Society

Peer Reviewed

1

DOI

10.1021/jf1041933

Link to Publisher's Edition

http://dx.doi.org/10.1021/jf1041933

ISSN (print)

00218561

ISSN (electronic)

15205118

ESSN

15205118

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