Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

Immunosuppressive decalin derivatives from red yeast rice

Language

English

Abstract

Five new decalin derivatives (15), together with two known compounds (6 and 7), were isolated from the ethyl acetate extract of red yeast rice. Their structures were elucidated by means of NMR and mass spectroscopic analyses. Monascusic lactone A (1) is the first reported naturally occurring decalin derivative possessing a spiro lactone at the C-1 position. The immunosuppressive effects of all these isolates (17) on human T cell proliferation were investigated, and all, especially monascusic acids B (2), C (3), D (4), and A (6) and heptaketide (7), suppressed human T cell proliferation in a dose-dependent manner from 10 to 100 μM. This is the first report on the immunosuppressive activity of decalin derivatives.

Publication Date

2012

Source Publication Title

Journal of Natural Products

Volume

75

Issue

4

Start Page

567

End Page

571

Publisher

American Chemical Society

Peer Reviewed

1

DOI

10.1021/np2007236

Link to Publisher's Edition

http://dx.doi.org/10.1021/np2007236

ISSN (print)

01633864

ISSN (electronic)

15206025

ESSN

15206025

This document is currently not available here.

Share

COinS