School of Chinese Medicine
The biological redundancies in molecular networks of complex diseases limit the efficacy of many single drug therapies. Combination therapeutics, as a common therapeutic method, involve pharmacological intervention using several drugs that interact with multiple targets in the molecular networks of diseases and may achieve better efficacy and/or less toxicity than monotherapy in practice. The development of combination therapeutics is complicated by several critical issues, including identifying multiple targets, targeting strategies and the drug combination. This review summarizes the current achievements in combination therapeutics, with a particular emphasis on the efforts to develop combination therapeutics for complex diseases.
Journal of Cellular and Molecular Medicine
Public Library of Science
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This work is supported by the Interdisciplinary Research Matching Scheme (IRMS) of Hong Kong Baptist University (RC-IRMS/12-13/02), the Research Committee of Hong Kong Baptist University (33-12-903), the Hong Kong Baptist University Strategic Development Fund (SDF13-1209-P01), the National Science and Technology Major Projects for ‘major New Drugs Innovation and Development’ (2013ZX09301307) and the Hospital Authority (HA 820/126/19/19/14/6/12/1).
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©2016 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
combination therapeutics, complex diseases, molecular network
He, Bing, Cheng Lu, Guang Zheng, Xiaojuan He, Maolin Wang, Gao Chen, Ge Zhang, and Aiping Lu. "Combination therapeutics in complex diseases." Journal of Cellular and Molecular Medicine 20.12 (2016): 2231-2240.