Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Abstract

The biological redundancies in molecular networks of complex diseases limit the efficacy of many single drug therapies. Combination therapeutics, as a common therapeutic method, involve pharmacological intervention using several drugs that interact with multiple targets in the molecular networks of diseases and may achieve better efficacy and/or less toxicity than monotherapy in practice. The development of combination therapeutics is complicated by several critical issues, including identifying multiple targets, targeting strategies and the drug combination. This review summarizes the current achievements in combination therapeutics, with a particular emphasis on the efforts to develop combination therapeutics for complex diseases.

Publication Year

2016

Journal Title

Journal of Cellular and Molecular Medicine

Volume number

20

Issue number

12

Publisher

Public Library of Science

First Page (page number)

2231

Last Page (page number)

2240

Referreed

1

Funder

This work is supported by the Interdisciplinary Research Matching Scheme (IRMS) of Hong Kong Baptist University (RC-IRMS/12-13/02), the Research Committee of Hong Kong Baptist University (33-12-903), the Hong Kong Baptist University Strategic Development Fund (SDF13-1209-P01), the National Science and Technology Major Projects for ‘major New Drugs Innovation and Development’ (2013ZX09301307) and the Hospital Authority (HA 820/126/19/19/14/6/12/1).

DOI

10.1111/jcmm.12930

ISSN (print)

15821838

Link to Publisher’s Edition

http://dx.doi.org/10.1111/jcmm.12930

Copyright

©2016 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Keywords

combination therapeutics, complex diseases, molecular network

ESSN

15824934

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