Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Language

English

Abstract

© 2016 by the authors; licensee MDPI, Basel, Switzerland. Osteosarcoma (OS) is a bone cancer mostly occurring in pediatric population. Current treatment regime of surgery and intensive chemotherapy could cure about 60%–75% patients with primary osteosarcoma, however only 15% to 30% can be cured when pulmonary metastasis or relapse has taken place. Hence, novel precise OS-targeting therapies are being developed with the hope of addressing this issue. This review summarizes the current development of molecular mechanisms and targets for osteosarcoma. Therapies that target these mechanisms with updated information on clinical trials are also reviewed. Meanwhile, we further discuss novel therapeutic targets and OS-targeting drug delivery systems. In conclusion, a full insight in OS pathogenesis and OS-targeting strategies would help us explore novel targeted therapies for metastatic osteosarcoma.

Keywords

Molecular mechanism, Molecular targets, Osteosarcoma, Targeted therapy

Publication Date

6-4-2016

Source Publication Title

International Journal of Molecular Sciences

Volume

4

Issue

17

Publisher

MDPI

Peer Reviewed

1

DOI

10.3390/ijms17040506

Link to Publisher's Edition

http://dx.doi.org/10.3390/ijms17040506

ISSN (print)

16616596

ISSN (electronic)

14220067

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