School of Chinese Medicine
© 2016 by the authors; licensee MDPI, Basel, Switzerland. Nucleic acids participate in a large number of biological processes. However, current approaches for small molecules targeting protein are incompatible with nucleic acids. On the other hand, the lack of crystallization of nucleic acid is the limiting factor for nucleic acid drug design. Because of the improvements in crystallization in recent years, a great many structures of nucleic acids have been reported, providing basic information for nucleic acid drug discovery. This review focuses on the discovery and development of small molecules targeting nucleic acids.
International Journal of Molecular Sciences
DNA drug discovery, Nucleic acids, Nucleic acids targeting, RNA drug discovery, Small molecules
Wang, Maolin, Yuanyuan Yu, Chao Liang, Aiping Lu, and Ge Zhang. "Recent advances in developing small molecules targeting nucleic acid." International Journal of Molecular Sciences 6.17 (2016).