Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Language

English

Abstract

© 2016 by the authors; licensee MDPI, Basel, Switzerland. Nucleic acids participate in a large number of biological processes. However, current approaches for small molecules targeting protein are incompatible with nucleic acids. On the other hand, the lack of crystallization of nucleic acid is the limiting factor for nucleic acid drug design. Because of the improvements in crystallization in recent years, a great many structures of nucleic acids have been reported, providing basic information for nucleic acid drug discovery. This review focuses on the discovery and development of small molecules targeting nucleic acids.

Keywords

DNA drug discovery, Nucleic acids, Nucleic acids targeting, RNA drug discovery, Small molecules

Publication Date

5-30-2016

Source Publication Title

International Journal of Molecular Sciences

Volume

6

Issue

17

Publisher

MDPI

Peer Reviewed

1

DOI

10.3390/ijms17060779

Link to Publisher's Edition

http://dx.doi.org/10.3390/ijms17060779

ISSN (print)

16616596

ISSN (electronic)

14220067

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