Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Abstract

Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC50 value of 9.1 µM (SI = 12.2).

Publication Year

2015

Journal Title

International Journal of Molecular Sciences

Volume number

11

Issue number

16

Publisher

MDPI

First Page (page number)

27978

Last Page (page number)

27987

Referreed

1

Funder

The work described in this paper was collaborative efforts within multi-disciplinary cooperative programs supported by grants from by the Natural Science Foundation Committee of China (81160496), the Science and Technology Fund of Guizhou Province (No. [2009]2145), the Research Grants Council of the Hong Kong Special Administrative Region, China (Project No. HKBU 262912 and HKBU12103014), HKBU Interdisciplinary Research Matching Scheme (RC-IRMS/12-13/03), and Faculty Research Grants, Hong Kong Baptist University (FRG2/14-15/047 and FRG1/13-14/029).

DOI

10.3390/ijms161126071

ISSN (print)

16616596

ISSN (electronic)

14220067

Link to Publisher’s Edition

http://dx.doi.org/10.3390/ijms161126071

Copyright

© 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

Keywords

Anti-HIV activity, Bioactivity evaluation, Ent-kaurane diterpene, Henrin A, Pteris henryi

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