Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Language

English

Abstract

Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC50 value of 9.1 µM (SI = 12.2).

Keywords

Anti-HIV activity, Bioactivity evaluation, Ent-kaurane diterpene, Henrin A, Pteris henryi

Publication Date

2015

Source Publication Title

International Journal of Molecular Sciences

Volume

11

Issue

16

Start Page

27978

End Page

27987

Publisher

MDPI

Peer Reviewed

1

Copyright

© 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

Funder

The work described in this paper was collaborative efforts within multi-disciplinary cooperative programs supported by grants from by the Natural Science Foundation Committee of China (81160496), the Science and Technology Fund of Guizhou Province (No. [2009]2145), the Research Grants Council of the Hong Kong Special Administrative Region, China (Project No. HKBU 262912 and HKBU12103014), HKBU Interdisciplinary Research Matching Scheme (RC-IRMS/12-13/03), and Faculty Research Grants, Hong Kong Baptist University (FRG2/14-15/047 and FRG1/13-14/029).

DOI

10.3390/ijms161126071

Link to Publisher's Edition

http://dx.doi.org/10.3390/ijms161126071

ISSN (print)

16616596

ISSN (electronic)

14220067

Share

COinS