School of Chinese Medicine
Monoclonal antibodies are the dominant agents used in inhibition of biological target molecules for disease therapeutics, but there are concerns of immunogenicity, production, cost and stability. Oligonucleotide aptamers have comparable affinity and specificity to targets with monoclonal antibodies whilst they have minimal immunogenicity, high production, low cost and high stability, thus are promising inhibitors to rival antibodies for disease therapy. In this review, we will compare the detailed advantages and disadvantages of antibodies and aptamers in therapeutic applications and summarize recent progress in aptamer selection and modification approaches. We will present therapeutic oligonucleotide aptamers in preclinical studies for skeletal diseases and further discuss oligonucleotide aptamers in different stages of clinical evaluation for various disease therapies including macular degeneration, cancer, inflammation and coagulation to highlight the bright commercial future and potential challenges of therapeutic oligonucleotide aptamers.
Clinical evaluation, Diseases therapy, Monoclonal antibodies, Oligonucleotide aptamers, Preclinical study
Source Publication Title
International Journal of Molecular Sciences
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
This study was supported by the Hong Kong General Research Fund (HKBU262913 to Ge Zhang).
Link to Publisher's Edition
Yu, Y., Liang, C., Lv, Q., Li, D., Xu, X., Liu, B., Lu, A., & Zhang, G. (2016). Molecular selection, modification and development of therapeutic oligonucleotide aptamers. International Journal of Molecular Sciences, 17 (3). https://doi.org/10.3390/ijms17030358